The objective of the Mission is to support at least 150 European regions and communities to become climate resilient by 2030. The Mission on Adaptation to Climate Change contributes to a recent area of policymaking, where there is little experience globally and in Europe, but where the EU has taken a bold step with its new EU Adaptation Strategy in 2021. The Mission deploys the new impact oriented approaches of European research and innovation policy in support of European Green Deal objectives (e.g. climate change adaptation, disaster risk, biodiversity). It becomes a key implementation vector of the 2021 EU Adaptation Strategy and will trigger co-ordinated R&I efforts across Horizon Europe. There is a firm expectation that the intended investment of ~1 billion EUR of Horizon Europe budget for the Mission will boost local adaptation efforts through engagement of citizens and local authorities and stimulate substantial additional investments from public and private sources. This will lead by 2030 to a much better knowledge in our regions on what climate change impacts to prepare for and how to prepare for them. A great number of regions will have seized the opportunity to take concrete actions and demonstrate solutions, which will inspire others to follow. This document lays out a plan on how to implement the Horizon Europe Mission on Climate Adaptation as advised in its scoping report by the Mission Board for Adaptation to Climate Change and Societal Transformations. More information in Greek Language.