Successful proposals should directly link their R&I coverage with other related intervention actions developing microbiome products and knowledge. In the medium term, food products grown and processed under optimised conditions favouring positive interactions with the microbiome must be harvested and delivered at comparable costs to those originating in today’s conventional farming or intensive agriculture systems. This should be achieved while ensuring that the microbiome-solutions have low risk for consumers, farmers and other users, and the environment, maintaining the economic balance of production facilities and preventing dramatic economic losses, in particular to primary producers.

Proposals are expected to address the following:

• The characterisation and development of microbiomes and their downstream products providing dietary diversity for improved human and animal health, and resilient food production systems.
• Mapping and provision of the arising co-benefits relevant to the four Food 2030 priorities: nutrition for sustainable healthy plant-based food and feed as well as those relevant to different socio-economic and cultural groups.
• Increasing knowledge and understanding of the biological and ecological processes involved in the assembly and dynamics of plant microbial communities, particularly microbial invasion and persistence, all along the production chains to deploy microbiota shaping-based strategies to improve the quality and safety of food products.
• Designing multi-objective multi-region microbiome/diet transition pathways for EU food systems, gathering all aspects of sustainable food systems and diets, health and safety parameters, biodiversity climate and environmental factors, circularity and resource efficiency, innovation and empowerment of communities, traditional and cultural resources.
• Seek international cooperation (such as with the International Bioeconomy Forum, the ‘one planet sustainable food systems’ programme, etc.), along with early and wide communication of microbiome science and applications.
• Address food industry needs, particularly personnel training in classical microbiology and modern microbiome skills; the closing of regulatory loopholes for microbial products; and the demarcation of research levels providing better differentiation to the companies developing the products.

Proposals are encouraged to build on past or ongoing EU-funded research, research infrastructures and collaborate with relevant initiatives, including the Horizon Europe mission in the area of soil health and food international cooperation, the International Bioeconomy Forum, the ‘one planet sustainable food systems’ programme, etc. The proposals should set out a clear plan on how it will collaborate with other related proposals selected under this and any other relevant topic/call, by participating in joint activities, workshops, as well as common communication and dissemination activities.