Social Circular Enterprises (SCEs) have been pioneers in the circular economy since decades. They are active in all stages of the circular economy and deal with various waste stream. SCEs are also known to offer new and innovative circular business models and brining new circular services and products to the market. In the last decade SCE also entered the market of secondary raw materials by collecting and dissembling various products and goods. The majority of SCEs are SMEs and offer local employment opportunities to vulnerable groups (99%). On average, a circular social enterprise creates 70 jobs per 1,000 tons collected with a view of being re-used.
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Demonstrators for clusters of social circular enterprises (IA)
ClosedCode: 37659 | Identifier Code: HORIZON-CL4-2025-05-TWIN-TRANSITION-21-two-stage | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 23/09/2025
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Enhanced logistics and operations of construction sites (IA)
ClosedCode: 37656 | Identifier Code: HORIZON-CL4-2025-05-TWIN-TRANSITION-11-two-stage | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 23/09/2025
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Development of safe and sustainable by design alternatives to Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) (IA)
ClosedCode: 37653 | Identifier Code: HORIZON-CL4-2025-05-MATERIALS-51-two-stage | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 23/09/2025
PFAS are a large class of substances used in a wide range of applications (for instance, as adhesives, coatings, lubricants, sealants, surfactants), for their technical and/or safety functions (e.g., water and oil repellence, antiadhesion, thermal & chemical stability). Nevertheless, PFAS have been detected in groundwater, surface water and soil, the remediation of which is extremely problematic. Their accumulation in the environment has been linked to negative effects for the wildlife and the human health, including carcinogenic, mutagenic, reprotoxic and toxic effects for the endocrine system. In January 2023, five national authorities submitted to the European Chemicals Agency (ECHA) a PFAS restriction dossier to ban the manufacture, placing on the market and use of PFAS as a chemical class in all uses, with few exemptions.
The Commission initiative for SSbD sets a framework which should be a reference in the proposal. The new alternatives to be developed should meet the technical functions required in the specific applications and align with such framework.
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Innovative Advanced Materials (IAMs) for robust, fast curing sealants and coatings for manufacturing and final assembly (IA) (Innovative Advanced Materials for Europe partnership)
ClosedCode: 37644 | Identifier Code: HORIZON-CL4-2025-05-MATERIALS-43-two-stage | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 23/09/2025
One of the main factors limiting the lifespan of products (and their components) is their prolonged exposure to environmental elements. The combination of different stressors and changing conditions (operational, daily, seasonal) results in accelerated aging and premature or unanticipated failures. To prevent the resulting adverse effects, protective coatings and sealings are key to provide additional protection without requiring the reassessment of the physical design of the product/component, nor the inherent properties of the parts to be coated/sealed.
Moreover, performance evaluation of coated samples to select coating solutions which meet the demands of industrial end users constitute another bottleneck in the fast development of IAM-based coatings. In addition, recyclability is often hampered by the sealants and coatings used. The new IAMs-based coatings, functionalised surfaces and sealings should allow to decompose products and structures into recyclable or reusable parts.
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Innovative Advanced Materials (IAMs) for product monitoring, smart maintenance and repair strategies in the construction sector (RIA) (Innovative Advanced Materials for Europe partnership)
ClosedCode: 37640 | Identifier Code: HORIZON-CL4-2025-05-MATERIALS-42-two-stage | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 23/09/2025
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EU-Japan cooperation on the exploitation of Quantum Space Gravimetry data
ClosedCode: 37637 | Identifier Code: HORIZON-CL4-2025-02-SPACE-81 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025
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Space Critical EEE Components for EU non-dependence – Advanced Packages and Memories
ClosedCode: 37635 | Identifier Code: HORIZON-CL4-2025-02-SPACE-74 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025
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Space Critical EEE Components for EU non-dependence – Connectors
ClosedCode: 37632 | Identifier Code: HORIZON-CL4-2025-02-SPACE-73 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025
Unrestricted access to state-of-art space EEE components and related technologies is a pre-requisite for the EU space industry responding to EU space missions. However, especially for some families of components, the available solutions in EU do not meet the current high-performance space requirements. Currently, alternative products sourced from outside EU, are either affected by non-EU export control, that limits its use, or present challenges in terms of trustable supply chains for the implementation of EU space missions with a security dimension.
Within the frame of this topic, it is expected to finance and implement development projects aiming at maturing critical space EEE components with the final goal of lowering the dependency from outside EU. This will be done by establishing a long-term sustainable supply chain for supporting EU strategic autonomy in the space sector. The selection of the supply chains shall reflect this objective. Therefore, the supply chain shall preferably be built fully based in EU and when this can only be achieved partially (i.e. because of lack of current EU capabilities for unrestricted advanced semiconductor processes or advanced materials that cannot be developed within the project), services procured from outside EU shall nevertheless ensure that the overall supply chain will remain trustable and not affected by non-EU export control. The latest scenario is subject to the approval of the granting authority.
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Space Critical Equipment and Related Technologies for EU non-dependence – Chip Scale Atomic Clocks and Solar Cells
ClosedCode: 37626 | Identifier Code: HORIZON-CL4-2025-02-SPACE-72 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025
Unrestricted access to state-of-art space equipment and related technologies is a pre-requisite for the EU space industry responding to EU space missions. However, especially for some families of equipment, the available solutions in EU do not meet the current high-performance space requirements and alternative products, sourced from outside EU, are either affected by non-EU export control with extra territorial applicability, that limit the access, re-export or raise challenges in terms of trustable supply chains for the implementation of EU space missions with a security dimension.
Within the frame of this topic it is expected to finance and implement development projects aiming at maturing critical space equipment with the final goal of lowering the dependency from outside EU, establish a long-term sustainable supply chain and support EU strategic autonomy in the space sector. The selection of the supply chains shall reflect this objective. Therefore, the supply chain shall preferably be built fully based in EU and when this can only be achieved partially (i.e. because of lack of current EU capabilities that cannot be developed within the project), services procured from outside EU shall nevertheless ensure that the overall supply chain will remain trustable and not affected by non-EU export control. The latest scenario is subject to the approval of the granting authority.
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Space Critical EEE Components for EU non-dependence – RISC-V Microprocessor on 7nm
ClosedCode: 37623 | Identifier Code: HORIZON-CL4-2025-02-SPACE-71 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025
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Innovative Earth observation services in support of maritime litter detection and ship source pollution policies
ClosedCode: 37621 | Identifier Code: HORIZON-CL4-2025-02-SPACE-46 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025
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Supporting the AI/ML digital transition of Copernicus Services
ClosedCode: 37618 | Identifier Code: HORIZON-CL4-2025-02-SPACE-45 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025
This R&I agenda focuses on integrating Artificial Intelligence and advanced data techniques to enhance Earth observation capabilities, especially within the Copernicus programme. Key priorities include developing AI-based retrieval algorithms for satellite sensing, improving cloud and shadow detection, and enabling multi-source segmentation. There’s emphasis on data fusion, mining, and compression methods to manage large datasets efficiently, as well as on hybrid and ensemble data assimilation to improve forecasts and analyses. The agenda also supports observation-driven forecasting and Earth system deep learning models for better prediction accuracy. Additionally, it explores the use of large pre-trained models, super-resolution applications, adaptive workflows, enhanced user interfaces, and AI-powered chatbots for improved user interaction with Copernicus services.
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Copernicus Marine Environment Monitoring Service (CMEMS) evolution: new and innovative ocean data assimilation techniques
ClosedCode: 37615 | Identifier Code: HORIZON-CL4-2025-02-SPACE-44 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025
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Copernicus Anthropogenic CO₂ Emissions Monitoring & Verification Support (CO2MVS) capacity: new and innovative methods to estimate the impact of fires on vegetation and related carbon fluxes
ClosedCode: 37613 | Identifier Code: HORIZON-CL4-2025-02-SPACE-43 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025
Research and innovation will focus on better understanding the impact of wildfires on the carbon cycle and emissions linked to land use change. A key priority is improving fire modelling, especially in relation to drought and vegetation interactions, which remains a challenge at regional and global scales. Initiatives like FireMIP have evaluated fire models, but the required model complexity is still uncertain. There is a need to integrate observation-based data into global systems like CO₂MVS to enhance monitoring. Additionally, understanding fire effects on vegetation will help refine estimates of emissions and improve air quality forecasting in systems like CAMS and fire risk predictions in CEMS.
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Copernicus Atmosphere Monitoring Service (CAMS) evolution: improved soil-vegetation-atmosphere modelling and data assimilation of atmospheric constituents
ClosedCode: 37610 | Identifier Code: HORIZON-CL4-2025-02-SPACE-42 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025
To achieve the expected outcomes, research and innovation will focus on improving models and techniques related to soil-vegetation-atmosphere interactions, evapotranspiration, and trace gas and aerosol dynamics. This includes enhancing numerical models, parameterizations, and data assimilation methods, particularly for CAMS (Copernicus Atmosphere Monitoring Service) systems. Additional priorities include refining methodologies for estimating deposition fluxes, developing accurate pollen source models for more allergenic species, exploring global pollen modelling, and increasing the use of satellite data to improve dry deposition and emission calculations.
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Improving the quality of life of persons with intellectual disabilities and their families
ClosedCode: 37608 | Identifier Code: HORIZON-HLTH-2025-03-STAYHLTH-01-two-stage | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025
The scope of this topic is set by the definitions provided by ‘The international classification of diseases’ – World Health Organization (WHO) ICD11 under ‘6A00: Disorders of intellectual development’ and under ‘20: Developmental anomalies’ including disorders of intellectual development, such as ‘LD40: Complete trisomies of the autosomes’ and ‘LD90: Conditions with disorders of intellectual development as a relevant clinical feature’.
Moreover, the three types of autism with disorders of intellectual development (6A02.1, 6A02.3 and 6A02.5) under ‘6A02: Autism spectrum disorder’ are also within the scope of this topic.
The focus of this topic is human-centred on the persons with long-term intellectual disabilities and their formal and informal carers, including families.
The life expectancy of persons with intellectual disabilities has increased in the last 20 years, which makes it even more important to analyse the role of their families acting as informal carers (e.g. ageing parents).
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Facilitating the conduct of multinational clinical studies of orphan devices and/or of highly innovative (“breakthrough”) devices
ClosedCode: 37605 | Identifier Code: HORIZON-HLTH-2025-03-IND-03-two-stage | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025
The focus of this topic is on multinational clinical studies of orphan devices and/or of highly innovative (“breakthrough”) devices, including digital and Artificial Intelligence (AI) based tools and techniques.
The emphasis within rare disease research and innovation has predominantly centred on pharmaceuticals, leaving a noticeable gap in the support for developing orphan devices.
Orphan devices are specifically intended for use in rare diseases or conditions or in specific indications for rare cohorts of patients with an otherwise non-rare disease or condition.
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Advancing knowledge on the impacts of micro- and nanoplastics on human health
ClosedCode: 37602 | Identifier Code: HORIZON-HLTH-2025-03-ENVHLTH-02-two-stage | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025
Plastics are an important material in our economy that are everywhere in our daily lives but can present negative environmental and health impacts.
A significant amount of plastic ends up in the environment, degrading into micro- or nano-sized plastic particles that are defined as micro- or nanoplastics (MNPs).
MNPs can be detected in both marine and terrestrial ecosystems worldwide in food, water, air and consumer products.
These MNPs have been documented to accumulate in the human body into cells and tissues (e.g. liver, kidney, gastrointestinal track, placenta, testicles) and cause associated adverse biological effects (e.g. inflammatory response, geno-, cyto-, neuro- and nephron-, respiratory and reproductive toxicity).
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The impact of pollution on the development and progression of brain diseases and disorders
ClosedCode: 37599 | Identifier Code: HORIZON-HLTH-2025-03-ENVHLTH-01-two-stage | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025
Life-long exposure to pollutants in the living and occupational environment is an important risk factor for non-communicable diseases, leading to a variety of serious physical and mental health impacts and causing preventable disease burden with associated elevated economic costs.
Pollution disproportionately impacts certain vulnerable groups (e.g. children and older adults) or groups who are more sensitive or more exposed (workers, populations living in polluted areas) to this type of environmental stressor.
At present, over 10% of annual premature deaths in the 27 EU Member States are related to environmental pollution.
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Copernicus Climate Change Service (C3S) evolution: new and innovative processing and methods for future Sentinels and other satellites for reanalyses
ClosedCode: 37594 | Identifier Code: HORIZON-CL4-2025-02-SPACE-41 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025




