ISOS Pilot Mission Detailed Design – Logistics component

Closed

Code: 37554 | Identifier Code: HORIZON-CL4-2025-02-SPACE-23 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025

To tackle the above expected outcomes, the following R&I actions should be addressed, taking into account the provided technical annex:

• R&I to complete ISOS Pilot mission detailed mission and system design (including relevant key technology maturation) for the logistics component, demonstrating the achievement of the required TRL for all relevant technologies;
• R&I on key enabling technologies relevant for design of a logistics component that can transport cargo (i.e., satAPPs and propellant) taken from an upper stage to the HOST component;
• R&I on solutions for docking and propellant management and transfer with the HOST. Building on existing European designs is encouraged;
• Contribution to the overall ISOS pilot mission detail design in close cooperation with other mission components, the ISOS Pilot Mission Coordination and Support Action and the ISOS Pilot Mission Advisory Group.

ISOS Pilot Mission Detailed Design – HOST component

Closed

Code: 37550 | Identifier Code: HORIZON-CL4-2025-02-SPACE-22 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025

To tackle the above expected outcomes, the following R&I actions should be addressed taking into account the provided technical annex:

• R&I to complete ISOS Pilot mission detailed mission and system design (including relevant key technology maturation) for the platform component (HOST), demonstrating the achievement of the required TRL for all relevant technologies;
• R&I on key enabling technologies relevant for design of a scalable, modular, flexible platform component, equipped with robotic manipulation, satAPPs compatibility and refuelling capability (for the HOST and the hosted servicer and logistic spacecraft), that can be extended and reconfigured to meet different demands (e.g., governmental and commercial, IOD/V and additional servicer hosting slots, robotic/manufacturing testbeds, warehouse and logistic node, etc.);
• Contribution to the overall ISOS pilot mission detail design in close cooperation with other mission components, the ISOS Pilot Mission Coordination and Support Action and the ISOS Pilot Mission Advisory Group;
• R&I on related HOST functions and applications including related operational concepts considering the use of distributed computing, multi-agent and network architectures and supported by simulations, enhancing the overall pilot mission system functionality.

ISOS Pilot Mission Detailed Design – Servicing component

Closed

Code: 37547 | Identifier Code: HORIZON-CL4-2025-02-SPACE-21 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025

To tackle the above expected outcomes, the following R&I actions should be addressed, taking into account the provided technical annex:

• R&I to complete detailed mission and system design (including relevant key technology maturation) for the servicing component as part of the ISOS pilot mission. More specifically, projects should finalise the detailed design for this component building on current or previous developments, demonstrating the achievement of the required TRL for all relevant technologies;
• Contribution to the overall ISOS pilot mission detail design in close cooperation with the other mission components (including other servicing components), the ISOS Pilot Mission Coordination and Support Action and the ISOS Pilot Mission Advisory Group;
• R&I on related service capabilities and applications including operational concepts for servicing individual or fleets of satellites based on the functionality of the pilot mission system design. More specifically, possible use case for servicing a real EU asset is expected to be developed up to delivery of a concept of operations (CONOPS).

Digital solutions for autonomy for space transportation systems, design and simulation tools – targeting demonstration

Closed

Code: 37544 | Identifier Code: HORIZON-CL4-2025-02-SPACE-13 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025

To tackle the above-mentioned expected outcomes, the following R&I should be addressed: R&I on advanced technologies and digital sensors for new space transportation, such as smart avionics with modularity and reusability drivers, health monitoring system and smart sensors, and structural health monitoring addressing thermo-mechanical monitoring and damage detection, ground and flight software for data management even by use of AI-algorithms.

The developments should aim at on-ground or in-orbit demonstration focusing on software and digital tools.

Support for the functioning of the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R)

Closed

Code: 37543 | Identifier Code: HORIZON-HLTH-2025-01-DISEASE-05 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

Recent history has illustrated the potential extent of threats posed by new or emerging infectious diseases, as well as the central importance of global collaboration and coordination to fight such regional or international challenges.

GloPID-R was established in 2013 for this reason, in response to a request for coordination by the Heads of International Research Organisations.

GloPID-R now provides a widely recognised platform for infectious disease research funders to work together to better tackle severe epidemics such as Ebola or Zika, pandemics at regional level that affect outermost regions, as well as global pandemics such as COVID-19.

Leveraging artificial intelligence for pandemic preparedness and response

Closed

Code: 37538 | Identifier Code: HORIZON-HLTH-2025-01-DISEASE-04 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

The COVID-19 pandemic underscored the need of finding innovative approaches to pandemic preparedness and response, including digital solutions leveraging AI technologies.

AI is a fast-developing field, holding an enormous potential in using the multitude of data from an equally vast range of sources, which should be used for improving preparedness and response to epidemics or pandemics in the EU and Associated Countries.

Digital solutions for autonomy for space transportation systems, design and simulation tools – Digital enablers and building blocks

Closed

Code: 37537 | Identifier Code: HORIZON-CL4-2025-02-SPACE-12 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025

To tackle the above-mentioned expected outcomes, the following R&I is expected to be addressed:

• the maturation of eco-design software tools enhancing reconfigurability in orbit
• the maturation of disruptive/game changing technologies related to digitalisation

Development of antibodies and antibody-derived proteins for the prevention and treatment of infectious diseases with epidemic potential

Closed

Code: 37534 | Identifier Code: HORIZON-HLTH-2025-01-DISEASE-03 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

As shown by the COVID-19 pandemic, infectious diseases remain a major threat to health and health security in the EU and globally.

Viral disease emergence is expected to accelerate due to among other, climate change, and thus a proactive approach to the development of antiviral prophylactics and therapeutics in preparedness for future infectious disease outbreaks is needed.

The availability of antibodies and antibody-derived proteins would provide a critical preparedness measure against future health threats, due to infectious disease epidemics or pandemics.

CSA on access to European spaceports

Closed

Code: 37529 | Identifier Code: HORIZON-CL4-2025-02-SPACE-11 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 25/09/2025

Testing safety and efficacy of phage therapy for the treatment of antibiotic-resistant bacterial infections

Closed

Code: 37528 | Identifier Code: HORIZON-HLTH-2025-01-DISEASE-01 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

Antimicrobial resistance (AMR) has been identified by the United Nations (UN) General Assembly as a health Emergency in 2016.

AMR is contributing to morbidity and mortality increasing the burden for society and healthcare costs.

This is due to a worrying increase on the number of bacteria resistant to antibiotic treatment, causing chronic and often life-threatening infections such as wound and urinary tract infections.

The World Health Organization (WHO) lists AMR among the top 10 threats for global health and recognises that a lack of innovation is set to undermine antibiotic performance and health gains, with a major gap in the discovery of innovative antibacterial treatments.

End user-driven application of Generative Artificial Intelligence models in healthcare (GenAI4EU)

Closed

Code: 37524 | Identifier Code: HORIZON-HLTH-2025-01-CARE-01 | Programme name: 2939 | Sub-program: Health (Cluster 1) (2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 16/09/2025

Healthcare professionals face important challenges related to efficiency, patient safety and provision of quality care with limited health systems’ resources.

Multimodality of health data combined with the available high-performance computing capabilities have the potential to empower effective and accurate use of trustworthy and ethical Generative AI-based solutions, augmented by other AI tools to address these challenges.

Generative AI may benefit patients, healthcare professionals and health systems.

Towards human-centric, sustainable and resilient energy-intensive industries (Processes4Planet and Clean Steel partnerships) (CSA)

Closed

Code: 37521 | Identifier Code: HORIZON-CL4-INDUSTRY-2025-01-TWIN-TRANSITION-39 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 23/09/2025

Industry 5.0 recognises the power of industry to achieve societal goals beyond jobs and growth to become a resilient provider of prosperity. It focuses on making production respect the boundaries of our planet improving competitiveness of European process industries and placing the wellbeing of the industrial worker at the centre of the production process, while increasingly embracing digital and green technologies to remain the solution provider for all Europeans.

Synergies and mutual learning with national and regional initiatives in Europe on Industrial decarbonisation (CSA)

Closed

Code: 37518 | Identifier Code: HORIZON-CL4-INDUSTRY-2025-01-TWIN-TRANSITION-38 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 23/09/2025

The governance of the action should be under the authority of national and regional governments and relevant public bodies who are responsible for national and regional policies, strategies and programmes addressing energy intensive industries.

Proposals should support the coordination of national and regional public authorities’ funding of research, innovation, acceleration of public/private R&I and deployment of technologies for the energy intensive industries’ decarbonisation. It should be aligned with the policies rolled out under the Clean Industrial Deal. The proposals should take into account and build on the Mutual Learning Exercise on Industrial Decarbonisation.

Solving issues in carbon-neutral iron and steel making processes with diverse input materials of varying quality (Clean Steel Partnership) (RIA)

Closed

Code: 37514 | Identifier Code: HORIZON-CL4-INDUSTRY-2025-01-TWIN-TRANSITION-37 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 23/09/2025

The topic calls for collaborative approach between academia, industry (including SMEs) and research organizations with the purpose to support: i) understanding, validating, and solving essential problems to allow maturity of innovative technologies in the industrial investment panorama for future carbon-neutral iron and steel making, ii) accelerating a reliable transition to climate neutrality in view of the end of the free ETS allowances by providing solutions optimized for different scenarios, and iii) fulfilling the Commission Recommendation 2024/774 on a Code of Practice on industry-academia co-creation for knowledge valorisation.

Safe and clean processing technologies and products (Processes4Planet partnership) (RIA)

Closed

Code: 37511 | Identifier Code: HORIZON-CL4-INDUSTRY-2025-01-TWIN-TRANSITION-36 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 23/09/2025

Whereas the release of pollutants by European industry has generally decreased during the last decade, and it is expected to continue to do so, industry still contributes significantly to the emission of many pollutants into the European environment. Pollution harms our health and our environment. In addition to affecting people’s health, pollution is one of the main reasons for the loss of biodiversity. Moreover, only emissions of historically important pollutants are reported by industry. Information on emerging and less known pollutants, especially those not regulated by the Industrial Emissions Directive, and related methods of monitoring is lacking. GHG emissions from industry are not included in the scope of this topic. Pollutant emissions to air, water and soil are considered.

Smart integration of net zero technologies into Energy Intensive industries (Processes4Planet and Made in Europe partnerships) (IA)

Closed

Code: 37507 | Identifier Code: HORIZON-CL4-INDUSTRY-2025-01-TWIN-TRANSITION-34 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 23/09/2025

As the industry decarbonises net-zero technologies can be applied to a wide range of energy intensive sectors and processes. Furthermore, the Net-Zero Industry Act which is part of the Green Deal Industrial Plan, is aiming at increasing the manufacturing capacity of strategic net-zero technologies to meet at least 40% of the EU’s annual deployment needs. In this framework the aim of this topic is to accelerate the deployment of net-zero technologies in at least one industrial sectors through a closer collaboration between, net-zero technology manufacturers and energy intensive industries.

Integrated use of renewable energy carriers in industrial sites (Processes4Planet partnership) (RIA)

Closed

Code: 37496 | Identifier Code: HORIZON-CL4-INDUSTRY-2025-01-TWIN-TRANSITION-33 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 23/09/2025

There is a broad range of renewable energy carriers (e.g., electricity, hydrogen, solar heat, ammonia, etc) which can be utilised in the process industries. Many of them are provided with significant temporal variations, e.g., renewable electricity and solar heat. Integrated design and operation of these highly complex systems within process industry sites are needed to cope with the fluctuations of the energy inputs and to achieve overall energy and cost efficiency. Industrial symbiosis and integration of production systems with energy systems in industrial sites can ensure overall emission reduction. These approaches can increase the efficiency of generation and enable solutions that avoid losses, supporting stability and efficiency of power systems.

Co-funded European partnership for Resilient Cultural Heritage

Closed

Code: 37493 | Identifier Code: HORIZON-CL2-2025-03-HERITAGE-01 | Programme name: 2939 | Sub-program: Culture, Creativity & Inclusive Societies (Cluster 2)(2021-2027) | Start submission calls: 15/05/2025 | End submission calls: 16/09/2025

The challenge of cultural heritage lies in preserving and safeguarding a society’s rich history, traditions, artefacts, and knowledge.

This involves addressing issues such as deterioration, damage, theft, conflict, changing societal values and new challenges such as the climate change.

In addition, it is essential to strike a balance between accessibility for future generations and respect for cultural sensitivities.

Green and resilient flexible production processes (Processes4Planet partnership) (IA)

Closed

Code: 37489 | Identifier Code: HORIZON-CL4-INDUSTRY-2025-01-TWIN-TRANSITION-32 | Programme name: 2939 | Sub-program: Digital, Industry & Space (Cluster 4)(2021-2027) | Start submission calls: 22/05/2025 | End submission calls: 23/09/2025

Flexibility of energy intensive production processes is a necessity for the use of alternative energy carriers as the supply of energy by renewable sources is subject to significant variations and the competitive potential of energy storage is limited. The optimal use of the renewable energy supply will require processes that can perform fast transitions to allow continuous and efficient operation when the renewable energy input varies. The limiting factor addressed by the topic is the ability of the production plants to promptly change loads and throughputs in large ranges without negative consequences for the equipment, while staying energy and resource efficient. Storage options and use of several sources of renewable energy can be included, the combination (hybridation) of various decarbonisation technologies can also be considered.

Innovative approaches to intangible cultural heritage for societal resilience

Closed

Code: 37488 | Identifier Code: HORIZON-CL2-2025-02-HERITAGE-02-two-stage | Programme name: 2939 | Sub-program: Culture, Creativity & Inclusive Societies (Cluster 2)(2021-2027) | Start submission calls: 15/05/2025 | End submission calls: 16/09/2025

Intangible cultural heritage (ICH) includes traditions, oral histories, performing arts, social practices, rituals, festive events, as defined by UNESCO. ICH represents a repository of traditional knowledge and forms the backbone of a community’s identity and continuity.