Innovative construction and maintenance, with the use of new materials and techniques, for resilient and sustainable transport infrastructure

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Code: 38323 | Identifier Code: HORIZON-CL5-2026-01-D6-07 | Programme name: 2939 | Sub-program: Climate, Energy and Mobility (Cluster 5)(2021-2027) | Start submission calls: 25/09/2025 | End submission calls: 20/01/2026

The overarching policy background is the European Grean Deal, which aims to achieve climate neutrality by 2050.

In the transport area, this translates into a 90% reduction of transport-related greenhouse gas emissions by 2050.

To deliver the European Green Deal, there is a need to revise and upgrade numerous policies, including those for transport and large-scale infrastructures.

 

Federated CCAM data exchange platform (CCAM Partnership)

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Code: 38320 | Identifier Code: HORIZON-CL5-2026-01-D6-06 | Programme name: 2939 | Sub-program: Climate, Energy and Mobility (Cluster 5)(2021-2027) | Start submission calls: 25/09/2025 | End submission calls: 20/01/2026

Data sharing plays a pivotal role in supporting R&I, enabling deployment, and enhancing the competitiveness of the CCAM industry.

Within the realm of data sharing, there are two distinct categories of data that are particularly pertinent:

1. mobility data, and
2. data for research and development.

The common European mobility data space aims to facilitate mobility data access and sharing, and is supported by projects, notably from the Digital Europe Programme.

Call for proposals for health data for biotech innovation leveraging the European Health Data Space

Opened

Code: 38317 | Identifier Code: EU4H-2026-SANTE-PJ-08 | Programme name: 10993 | Start submission calls: 23/09/2025 | End submission calls: 06/01/2026

The general objective of this action is to accelerate the development and deployment of AI and digital solutions in the biotech sector driven by health data, ensuring its secure and responsible use through the EHDS and leveraging AI Factories to augment these efforts.

Approaches, verification and training for Edge-AI building blocks for CCAM Systems (CCAM Partnership)

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Code: 38315 | Identifier Code: HORIZON-CL5-2026-01-D6-05 | Programme name: 2939 | Sub-program: Climate, Energy and Mobility (Cluster 5)(2021-2027) | Start submission calls: 25/09/2025 | End submission calls: 20/01/2026

CCAM-enabled vehicles are constantly sensing their surroundings on road conditions, location, nearby vehicles and infrastructure. Such data is shared in real-time, while data from other sources is received.

This needs powerful and optimised large data processing algorithms, which requires large amounts of computing power, data processing, real-time operation and high levels of security.

However, most existing AI computing tasks for automated vehicle applications are relying on general-purpose hardware, which has limitations in terms of power consumption, speed, accuracy, scalability, memory footprint, size and cost.

Hardware advancements driven by initiatives such as the Chips JU calls must be complemented by significant efforts to optimise AI algorithms for CCAM functionalities, ensuring their efficient performance on edge-specific hardware.

Call for proposals for a programme on orphan medical devices, in particular targeting paediatric patients

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Code: 38310 | Identifier Code: EU4H-2026-SANTE-PJ-07 | Programme name: 10993 | Start submission calls: 23/09/2025 | End submission calls: 06/01/2026

This action aims to support innovation in the field of medical devices by supporting non-profit organisations or consortia that provide a platform for academic bodies, scientific societies, developers of devices, in particular SMEs, and NGOs with a specific interest in innovative medical devices to help foster and guide the development of orphan devices, in particular in areas of unmet medical needs and paediatric patients.

Integration of human driving behaviour in the validation of CCAM systems (CCAM Partnership)

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Code: 38309 | Identifier Code: HORIZON-CL5-2026-01-D6-04 | Programme name: 2939 | Sub-program: Climate, Energy and Mobility (Cluster 5)(2021-2027) | Start submission calls: 25/09/2025 | End submission calls: 20/01/2026

The deployment of CCAM systems in mixed traffic will mean intense interaction with all road users such as the human drivers of other vehicles as well as pedestrians and riders of two-wheelers. These interactions (including implicit and explicit communication by humans and CCAM systems) will play a crucial role in the acceptance and thereby the penetration of CCAM systems in future road transport.

CCAM systems will have to show safe and human-like driving behaviour, so that their decisions and actions can be anticipated easily by all road users, respecting the variety of typical driving behaviour across different countries as well as the need for CCAM systems to respect traffic rules and support road safety.

Call for proposals to support the development of a medicine pricing, reimbursement and access tracker through the EURIPID database

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Code: 38306 | Identifier Code: EU4H-2026-SANTE-PJ-06 | Programme name: 10993 | Start submission calls: 23/09/2025 | End submission calls: 06/01/2026

In the short term, this action will provide EURIPID members with a better overview of access, P&R measures and decisions across the Member States.

In the longer term, it is expected to support mutual learning between national authorities and help the Member States in taking better pricing and reimbursement decisions, with a view to improve access, availability, and affordability of medicines. This is in line with the recommendations in the Draghi Report on the future of European competitiveness, and with the priority to ensure supply of affordable medicines, as outlined in the mission letter from Commission President von der Leyen to the Commissioner for Health and Animal Welfare.

The proposed “pricing and reimbursement (‘P&R’) tracker” and access dashboard will allow improved monitoring of patients’ access to medicines across the Union, including for cancer treatments. Having this data available prior to the application of the proposed pharmaceutical reform, will serve to measure the baseline and subsequently the impact of the proposed measures that aim to increase access to medicines across the Union, including for cancer treatments.

Next-generation environment perception for real world CCAM operations: Error-free and secure technologies to improve energy-efficiency, cost-effectiveness, and circularity (CCAM Partnership)

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Code: 38304 | Identifier Code: HORIZON-CL5-2026-01-D6-03 | Programme name: 2939 | Sub-program: Climate, Energy and Mobility (Cluster 5)(2021-2027) | Start submission calls: 25/09/2025 | End submission calls: 20/01/2026

The initial deployment of Level 4 automated vehicle services in urban and other complex settings has encountered significant challenges in environmental perception and decision-making, leading to occasional remote assistance calls, blockages and accidents that have impacted public trust.

At the same time, the increasing computing power demand is in conflict with a limited usage of energy and resources to meet sustainability requirements.

Thus, emerging large-scale demonstrations of automated vehicles should be accompanied by objective-oriented research aimed at addressing these challenges directly, while targeting improvements in performance, accuracy, reliability, and cyber-security.

Real time monitoring of regulated and non-regulated emissions from all types of vessels and other port activities in order to enforce emission limits in waterfront cities

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Code: 38301 | Identifier Code: HORIZON-CL5-2026-01-D5-17 | Programme name: 2939 | Sub-program: Climate, Energy and Mobility (Cluster 5)(2021-2027) | Start submission calls: 25/09/2025 | End submission calls: 20/01/2026

There is a pressing need to measure accurately the different types of emissions in coastal and port environments located near to cities, because of their negative impact on the environment and human health.

Ports, as intricate environments showcasing a variety of vessels including novel designs, pose a challenge to the development of standardised technologies capable of collecting and assessing real-time pollutant emissions data from these ships docking at ports.

This is vital for enforcing emissions limits and validating the data for enforcement purposes.

Monitoring and Evaluation of the Societal Readiness Pilot

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Code: 38298 | Identifier Code: HORIZON-CL5-2026-01-D2-09 | Programme name: 2939 | Sub-program: Climate, Energy and Mobility (Cluster 5)(2021-2027) | Start submission calls: 25/09/2025 | End submission calls: 20/01/2026

The European Commission has a strong interest in learning from the implementation of Societal Readiness actions piloted in eight topics from the Cluster 5 work programme 2025, and resulting in an estimate of eighteen projects to be implemented.

Conclusions on the pilot’s monitoring and evaluation will be the basis for the European Commission’s decision to replicate further these actions, to improve its implementation and possibly widen its use to other fields of application.

The instructions and definitions applying to pilot topics are included in the introduction of the Horizon Europe Main Work Programme 2025 for Climate, Energy and Mobility.

Call for proposals on lifelong prevention for a healthy life with focus on cardiovascular diseases

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Code: 38292 | Identifier Code: EU4H-2026-SANTE-PJ-05 | Programme name: 10993 | Start submission calls: 23/09/2025 | End submission calls: 06/01/2026

The aim of this action is to contribute to reducing the burden of non-communicable diseases, including cancer, and their risk factors across the lifespan, supporting Member States’ actions.

A European flagship initiative leveraging AI and health data for cardiovascular health and related non-communicable diseases: Advancing Risk Prediction, Prevention, Treatments, Personalised Care and Rehabilitation

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Code: 38290 | Identifier Code: EU4H-2026-SANTE-PJ-04 | Programme name: 10993 | Start submission calls: 23/09/2025 | End submission calls: 06/01/2026

Improved health outcomes: Earlier diagnosis and more targeted prevention of NCDs, leading to reduced disease progression, complications, and avoidable mortality.

Greater equity: Enhanced access to personalised diagnostics and AI-supported care pathways, especially in underserved regions or Member States with limited innovation capacity.

Efficiency and sustainability of health systems: Better use of resources through predictive and preventive approaches, reducing the burden of chronic conditions on healthcare infrastructures.

Trust in European health AI: By ensuring compliance with data protection, safety, and transparency standards, the initiative will foster trust in the responsible use of AI for health in line with the AI Act and EHDS Regulation. It will also support the uptake — and where relevant, the development — of specifications and standards foreseen under both frameworks, notably for interoperability, risk management and data governance

Accelerated multi-physical and virtual testing for battery aging, reliability, and safety evaluation (Batt4EU Partnership)

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Code: 38283 | Identifier Code: HORIZON-CL5-2026-01-D2-05 | Programme name: 2939 | Sub-program: Climate, Energy and Mobility (Cluster 5)(2021-2027) | Start submission calls: 25/09/2025 | End submission calls: 20/01/2026

This topic aims to reduce development costs and time to market of new battery systems by accelerated multi-physical and virtual testing. Current test strategies are still very time consuming and costly due to the need to understand the impact of multi-physical operational loads (electric, thermal, mechanical, etc.), potential failure modes, ageing and misuse on the safety and reliability of battery cells and modules.

To overcome these barriers, new multi-physical test strategies supplemented by virtual testing are required taking into account the most impactful parameters on ageing, reliability and safety and their dependencies.

Integrating advanced materials, cell design and manufacturing development for high-performance batteries aimed at mobility (Batt4EU Partnership)

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Code: 38280 | Identifier Code: HORIZON-CL5-2026-01-D2-04 | Programme name: 2939 | Sub-program: Climate, Energy and Mobility (Cluster 5)(2021-2027) | Start submission calls: 25/09/2025 | End submission calls: 20/01/2026

The scope covers quasi-solid and all-solid-state lithium-ion battery technologies (up to 5% liquid electrolyte weight percentage) which encompasses Si-C composite anodes or lithium metal anodes.

Development of sustainable and design-to-cost batteries with (energy-)efficient manufacturing processes and based on advanced and safer materials (Batt4EU Partnership)

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Code: 38277 | Identifier Code: HORIZON-CL5-2026-01-D2-01 | Programme name: 2939 | Sub-program: Climate, Energy and Mobility (Cluster 5)(2021-2027) | Start submission calls: 25/09/2025 | End submission calls: 20/01/2026

Proposals are expected to target technologies for design-to-cost batteries, with little reliance on CRMs, from one of the following two main technologies:

• Liquid electrolyte lithium-ion batteries with lithium manganese iron phosphate (LMFP) or manganese-rich HLM (high lithium, manganese) as cathode materials (design-to-cost lithium-ion batteries for mobility);
• Sodium-ion batteries for mobility applications.

Call for proposals to pilot and implement cancer screening programmes for prostate cancer

Opened

Code: 38275 | Identifier Code: EU4H-2026-SANTE-PJ-03 | Programme name: 10993 | Start submission calls: 23/09/2025 | End submission calls: 06/01/2026

This action will contribute to the implementation of prostate cancer screening programmes, in a stepwise approach to ensure the gradual and appropriate planning, piloting, and roll-out of the screening programmes within national priorities, as called for in the 2022 Council Recommendation and upcoming European Guidelines on cancer screening. The use of AI in ongoing (pilot) programmes shall be assessed, and the potential use of AI, where feasible, further be explored. Synergies with actions implementing the European Cancer Imaging Initiative, in particular the Cancer Image Europe platform, shall be explored. Potential synergies with the project stemming out of the “Call for proposals on advancing the adoption of artificial intelligence in health” (DI-g-24-76 from 2024 EU4Health work programme) shall be explored.

Call for proposals to pilot and implement cancer screening programmes for lung cancer

Opened

Code: 38272 | Identifier Code: EU4H-2026-SANTE-PJ-02 | Programme name: 10993 | Start submission calls: 23/09/2025 | End submission calls: 06/01/2026

This action will contribute to the implementation of lung cancer screening programmes, to enhance early detection and programme efficiency. The gradual and appropriate planning, piloting, and roll-out of the screening programs will align with national priorities and the latest scientific advancements as called for in the 2022 Council Recommendation on cancer screening. The use of AI in ongoing (pilot) programmes shall be assessed, and the potential use of AI, where feasible, further be explored. Synergies with actions implementing the European Cancer Imaging Initiative, in particular the Cancer Image Europe platform, shall be explored. Potential synergies with the project stemming out of the “Call for proposals on advancing the adoption of artificial intelligence in health” (DI-g-24-76 from the 2024 EU4Health Work Programme) shall be explored.

Call for proposals to pilot and implement cancer screening programmes for gastric cancer

Opened

Code: 38269 | Identifier Code: EU4H-2026-SANTE-PJ-01 | Programme name: 10993 | Start submission calls: 23/09/2025 | End submission calls: 06/01/2026

This action will contribute to the implementation of gastric cancer screening programmes, in a stepwise approach to ensure the gradual and appropriate planning, piloting, and roll-out of the screening programmes within national priorities, as called for in the 2022 Council Recommendation on cancer screening. The use of AI in ongoing (pilot) programmes shall be assessed, and the potential use of AI, where feasible, further be explored. Potential synergies with the project stemming out of the “Call for proposals on advancing the adoption of artificial intelligence in health” (DI-g-24-76 of 2024 EU4Health work programme) shall be explored.

Phase out fossil fuel in energy intensive industries through the efficient integration of renewable energy sources

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Code: 38265 | Identifier Code: HORIZON-CL5-2026-02-D4-06 | Programme name: 2939 | Sub-program: Climate, Energy and Mobility (Cluster 5)(2021-2027) | Start submission calls: 16/09/2025 | End submission calls: 17/02/2026

Proposals are expected to demonstrate an innovative solution for the efficient, long lasting and cost-effective local integration of one or a combination of renewable thermal, electrical, bioenergy and other renewable energy sources in industrial processes, for heating, cooling and power generation, while optimising process efficiency and reuse, possibly upgrade of excess heat, with the aim of avoiding or drastically reducing fossil fuel use.

Optimal combination of low embodied carbon construction products, technical building systems and circularity principles for climate neutral buildings (Built4People Partnership)

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Code: 38261 | Identifier Code: HORIZON-CL5-2026-02-D4-05 | Programme name: 2939 | Sub-program: Climate, Energy and Mobility (Cluster 5)(2021-2027) | Start submission calls: 16/09/2025 | End submission calls: 17/02/2026

Buildings result in greenhouse gas emissions over their whole life cycle (operational and embodied emissions). Buildings can also contribute to long-term carbon removals by storing carbon in construction products.

Construction and renovation works must also meet a variety of inter-related requirements such as structural and fire safety, acoustics, and a healthy and comfortable indoor environment.

Although much research has focused on developing materials and products with reduced whole life carbon emissions, the life cycle impacts of buildings depend on a complex interaction between individual products, components and technical building systems, spatial distribution, usage during their lifetime, and other design choices.

There is therefore a need to deliver buildings and renovation works with minimal life cycle impacts, in particular global warming potential, based on circularity principles, also accommodating future building use-change through design for flexibility, and using innovative combinations of products and systems that result in optimal building-level performance.