Accelerating the development of prophylactic vaccines against Neglected Tropical Diseases (NTDs) in sub-Saharan Africa

Code: 35765 | Identifier Code: HORIZON-JU-GH-EDCTP3-2025-01-NTD-03-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 30/01/2025 | End submission calls: 02/09/2025

This topic aims at supporting activities that contribute to one or several of the expected impacts for this call.
Proposals submitted under this topic should aim for delivering results that are directed, tailored towards and contributing to following one of the expected outcomes:

• Generate data on novel or existing vaccines (Phase II/Phase III trials) to make progress towards prevention, control and elimination of NTDs in SSA (note: in case of no or limited vaccine candidates in development, early development is encouraged (Phase I onwards);
• Improve the understanding of barriers for progression of new or improved vaccines against NTDs through the R&D pipeline;
• Generate clinical data including pregnant and lactating women, new-borns, children, adolescents, other vulnerable and neglected populations, and people with co-infections and co-morbidities at risk in SSA as relevant.

The objective of the topic is to progress the development of prophylactic vaccines against Neglected Tropical Diseases (NTDs) in sub-Saharan Africa.

Global collaboration action for research on existing Malaria therapeutics and clinical development of new antimalarial candidates

Code: 35763 | Identifier Code: HORIZON-JU-GH-EDCTP3-2025-01-MALARIA-02-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 30/01/2025 | End submission calls: 02/09/2025

This topic aims at supporting activities that contribute to one or several of the expected impacts for this call.
Proposals submitted under this topic should aim for delivering results that are directed, tailored towards and contributing to at least two of the following expected outcomes:

• Generate clinical data progressing development of new or improved antimalarial treatment regimen combatting drug resistance;
• Progress new drug(s) and/or drug combinations towards registration for treatment of malaria in SSA;
• Generate clinical data on special populations, including pregnant women, neo-nates, infants, children, adolescents and immune-compromised individuals living in high transmission regions;
• Generation of evidence on resistance to current treatments including combined therapies, as secondary outcome.

Proposals submitted under this topic are expected to advance the clinical development of existing and new antimalarial candidates.

Global collaboration action for the development of vaccines for reducing the disease burden of Tuberculosis in sub-Saharan Africa

Code: 35761 | Identifier Code: HORIZON-JU-GH-EDCTP3-2025-01-TB-01-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 30/01/2025 | End submission calls: 02/09/2025

The objective of the topic is to progress the development of vaccine candidates under development and licensed TB vaccines, especially targeting the population in low-middle countries, particularly in SSA.

The actions funded under this topic should contribute to increased international cooperation among researchers and funders, catalyse research synergies, and leverage resources and investments in order to achieve the reduction of disease burden in SSA through the development of vaccines.

Transformative Innovations in global health

Code: 35759 | Identifier Code: HORIZON-JU-GH-EDCTP3-2025-04-ACCESS-02-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 30/01/2025 | End submission calls: 20/03/2025

This topic aims at supporting activities that contribute to one or several of the expected outcomes for this call.
Proposals under this topic should aim to deliver results that are contributing to at least one of the following expected outcomes:

• Generate beyond proof of concept data with innovative ideas or inventions that will improve the uptake, adherence or implementation of preventative/treatment/diagnostic solutions;
• Progress an innovative approach that makes products and services (more) accessible and affordable to commercially unattractive markets or serves vulnerable populations in SSA;
• Progress an innovative approach that addresses community-driven and trusted demand for new or repurposed tools, including those needed by hard-to-reach communities;
• Deliver innovative technologies which can generate accelerated cross-disease solutions, including communicable disease specific solutions;
• Repurpose or extend the use of an existing preventative/treatment/diagnostic intervention.

Global collaborative action tackling Diarrhoeal Diseases in the context of Climate and Health

Code: 35756 | Identifier Code: HORIZON-JU-GH-EDCTP3-2025-04-CH-01-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 30/01/2025 | End submission calls: 20/03/2025

This topic aims to reduce or manage the potential adverse consequences for diarrhoeal diseases by contributing to at least two of the following expected outcomes, with the first being mandatory:

• Develop interventions to identify and control diarrhoeal diseases through generating late-stage clinical data in sub-Saharan Africa;
• Implementation research combining interventions with current standard of care (including vaccines);
• Generate evidence to evaluate the populations and geographies of most vulnerable to diarrheal diseases, understand the key underlying factors including those related to climate change, and understand the barriers to protect the people affected.

Global collaborative action for strengthening the Regional Networks of Excellence and Epidemic Preparedness Consortia (CSA)

Code: 35753 | Identifier Code: HORIZON-JU-GH-EDCTP3-2025-03-NETWORKS-01-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 30/01/2025 | End submission calls: 02/09/2025

The purpose of this topic is to provide funding to restructured EDCTP Regional Networks tailored to the evolving regional clinical trials landscape and learnings from COVID-19, as well as other regional disease threats, towards achieving the pre-defined deliverables set out in this call. Building on EDCTP investments, proposals under this topic should aim to deliver results that are directed, tailored towards, and contributing to the following expected outcomes.

Global Health EDCTP3 JU training fellowship with return phase

Code: 32407 | Identifier Code: HORIZON-JU-GH-EDCTP3-2024-02-01-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 18/01/2024 | End submission calls: 12/09/2024

Proposals submitted to this topic should implement a master’s level training programme in a discipline relevant for the Global Health EDCTP3 JU, providing transferable R&D skills, fostering innovation and entrepreneurship, incl. commercialisation of results, Intellectual Property Rights, communication, public engagement, and citizen science. The training provided by the academic institutions is expected to be complemented by training modules provided by pharmaceutical companies. It is expected that pharmaceutical companies will join the consortium as beneficiaries and/or associated partners at a later stage. The companies are expected to bring cash or in-kind contributions to the training programme for the fellows.

The training will address the research and development value chain from pre-clinical to clinical research including pharmaceuticals and vaccines.

Innovative digital health solutions for sub-Saharan Africa

Code: 32393 | Identifier Code: HORIZON-JU-GH-EDCTP3-2024-01-06-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 18/01/2024 | End submission calls: 12/09/2024

This topic focuses on innovative digital health solutions for sub-Saharan Africa. Integration of digital health innovations in national and/or regional strategies and context will be instrumental to ensure long-term impact and sustainability.

New tools, technologies and approaches for vector control in sub-Saharan Africa

Code: 32391 | Identifier Code: HORIZON-JU-GH-EDCTP3-2024-01-05-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 18/01/2024 | End submission calls: 12/09/2024

This topic focuses on new tools, technologies and approaches for vector control in sub-Saharan Africa.
Proposals under this topic should aim to deliver results that are directed, tailored towards, and contributing to the development and evaluation of tools, technologies and approaches for vector-borne diseases, including vector control and disease management technologies.
This topical area should be innovative interventions that target any vector-borne disease including transmission through mosquitos, ticks, flies, fleas, lice, aquatic snails, and bugs.

Tackling Antimicrobial Resistance (AMR) through R&D in novel and existing antimicrobials

Code: 32389 | Identifier Code: HORIZON-JU-GH-EDCTP3-2024-01-04-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 18/01/2024 | End submission calls: 12/09/2024

This topic focuses on Tackling Antimicrobial Resistance (AMR) through R&D in novel and existing antimicrobials. Tackling AMR requires multi-modal interventions, the collaboration of many disciplines and countries. Antimicrobial stewardship (AMS) could further reduce the burden of drug-resistant infection. The WHO defines AMS as a coherent set of integrated actions which promote the responsible and appropriate use of antimicrobials to help improve patient outcomes across the continuum of care. Responsible and appropriate use of antimicrobials includes prescribing only when needed, selection of the optimal drug regime, drug dosing, route of administration and duration of treatment following proper and optimized diagnosis. These actions are complemented by the implementation of infection prevention and control (IPC), enhancing water, sanitation and hygiene (WASH), and optimizing vaccination coverage.

AMR is one of the Global Health issues which can hugely benefit from the employment of the One Health approach. AMR transmission is a critical global problem affecting humans, the environment, and animals. Hence, proposals need to have the One Health approach at their centre.

Furthermore, the availability and access to existing antibiotics is also a challenge. In particular, efforts to ensure equitable access to antibiotics in LMICs that experience the highest burden of AMR, are needed.

Accelerating development and integration of therapeutics against Neglected Tropical Diseases (NTDs) in sub-Saharan Africa

Code: 32387 | Identifier Code: HORIZON-JU-GH-EDCTP3-2024-01-03-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 18/01/2024 | End submission calls: 12/09/2024

Diseases such as schistosomiasis, onchocerciasis, and other NTDs continue to affect hundreds of millions of people who are most often society’s poorest, in sub-Saharan Africa.
Many of NTDs are vector-borne diseases, have animal reservoirs and are associated with complex life cycles. The epidemiology of NTDs is complex and multifactorial, often related to environmental conditions, that makes their public-health control challenging. Pharmaceutical interventions combined with interventions such as house improvements, improved access to safe water, sanitation and hygiene (WASH) are also critical in the prevention for the majority of the NTDs, especially for Trachoma, Soil-transmitted helminthiases (STHs), Schistosomiasis and Dracunculiasis.
Therefore, accelerating development and integration of therapeutics against Neglected Tropical Diseases (NTDs) in sub-Saharan Africa.

Research on existing Malaria vaccines and development of new promising candidates

Code: 32385 | Identifier Code: HORIZON-JU-GH-EDCTP3-2024-01-02-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 18/01/2024 | End submission calls: 12/09/2024

This topic focuses on research on existing Malaria vaccines and development of new promising candidates. Specifically, Malaria requires a multidimensional approach, including more and better vaccine strategies. Therefore, further R&D on other promising candidates in the pipeline is required, and further research on cross-cutting issues is necessary, to ensure both pharmaceutical and non-pharmaceutical prevention strategies are part of future evidence-based malaria prevention and control measures. Synergy between researchers and other relevant stakeholders is required to develop and strengthen vaccines manufacturing capacity and to build an efficient supply chain in sub-Saharan Africa.

Developing novel, innovative HIV therapeutics for reducing the disease burden of HIV in sub-Saharan Africa

Code: 32383 | Identifier Code: HORIZON-JU-GH-EDCTP3-2024-01-01-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 18/01/2024 | End submission calls: 12/09/2024

There is a strong need to achieve the 2030 UNAIDS 95-95-95 target and develop novel HIV therapeutics, novel clinical delivery modes for their administration and novel biomarkers for optimising treatment decisions in sub-Saharan Africa.

Advancing point-of-care diagnostics to the market

Code: 29829 | Identifier Code: HORIZON-JU-GH-EDCTP3-2023-02-02-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 27/06/2023 | End submission calls: 28/09/2023

Proposal under this topic should aim to deliver results that are directed towards, and contributing to all of the following expected outcomes:

• Health care providers and professionals have access to novel or improved point-of-care diagnostic (POC) devices that are suited to rapidly detect infectious diseases of relevance in sub-Saharan Africa (SSA) and within the scope of the Global Health EDCTP3 Scientific Research and Innovation Agenda.
• A diverse and robust pipeline of in vitro diagnostics is available, increasing options for clinical deployment, also in case of an infectious diseases outbreak with epidemic or pandemic potential, that can reach the most vulnerable populations.
• Health authorities and health care systems have access to health data and evidence to better develop and implement informed health policies and improved clinical surveillance of infectious diseases in SSA.

Improving modes of delivery, deployment, and uptake of vaccines through phase IV/implementation research

Code: 29827 | Identifier Code: HORIZON-JU-GH-EDCTP3-2023-02-01-two-stage | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 27/06/2023 | End submission calls: 28/09/2023

Proposals submitted under this topic should aim for delivering results that are directed to all the following expected outcomes:

• Public health authorities and health care professionals in sub-Saharan Africa (SSA) have access to novel logistical and clinical solutions for vaccine delivery and have a better understanding of the behavioural barriers driving vaccine hesitancy, resulting in improved rates of vaccine deployment and uptake, particularly in poor and vulnerable communities.
• People in SSA have improved access, coverage, and trust in vaccines against all preventable infectious diseases within the scope of the Global Health EDCTP. Better tools as well as data on immunisation levels and the individual and public health benefit of immunization will drive vaccination even in hard-to-reach regions, thus helping to contribute towards the WHO Immunization Agenda.
• Health professionals and especially clinicians as well as policy makers have access to comprehensive phase IV/implementation research results, making use of them to ensure widespread translation and adoption of research findings into national and international policy guidelines for better delivery, deployment, and uptake of vaccines in clinical practice in SSA.

Funding to successfully finalise EDCTP2-funded clinical trials that were negatively impacted by the COVID-19 pandemic

Code: 29129 | Identifier Code: HORIZON-JU-GH-EDCTP3-2023-01-02 | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 10/05/2023 | End submission calls: 29/06/2023

This topic focuses on the clinical trials of medical technologies that were funded by EDCTP2 and whose activities were disrupted during the COVID-19 pandemic.
Information about medical technologies can be used by health care professionals and health care systems.

Research to rapidly evaluate interventions on Ebola outbreaks in sub-Saharan Africa

Code: 29127 | Identifier Code: HORIZON-JU-GH-EDCTP3-2023-01-04 | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 10/05/2023 | End submission calls: 29/06/2023

Proposals submitted under this call topic are expected to advance knowledge on Ebola virus disease with the aim of contributing to an efficient patient management and public health response, as well as better epidemic preparedness in Africa. Special focus should be on improving our understanding of the Sudan virus disease, in view of the recent outbreak in East Africa and the lack of available interventions for this viral strain.

Implementation research/real life assessment of existing interventions in women and children’s health

Code: 29125 | Identifier Code: HORIZON-JU-GH-EDCTP3-2023-01-03 | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 10/05/2023 | End submission calls: 29/06/2023

This topic is focused on the need for critical appraisal of existing health interventions, which may have been introduced and used by healthcare systems without rigorous evaluation in clinical trials. It is thus important to understand whether such interventions lead to better overall health in these populations.
Concerted efforts are needed to increase access to potentially lifesaving, cost-effective interventions to prevent and treat PRDs and other diseases such as diarrhoeal diseases, bacterial infections (especially those where antimicrobial resistance is an issue), sepsis and lower respiratory tract infections in pregnant women, newborns, and children to ensure solid evidence is produced for the recommended interventions and to enhance the use of existing interventions in these populations.

Strengthening ethics and regulatory capacity

Code: 29123 | Identifier Code: HORIZON-JU-GH-EDCTP3-2023-01-05 | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 10/05/2023 | End submission calls: 29/06/2023

The aim of this call is to improve the functionality, recognition and performance of NECs and NRAs for carrying out clinical trials in SSA countries.

The projects funded under this call will support the SSA countries to establish and/or develop own robust capacities for ethics review and national medicines regulatory systems. This also includes support towards national and international collaboration in compliance with established international standards. This scheme targets proposals with active involvement of NECs and/or NRAs from SSA countries, and in particular with those countries with the highest infectious disease burden.

Global Health EDCTP3 Training Networks - Clinical Research Fellowships

Code: 29120 | Identifier Code: HORIZON-JU-GH-EDCTP3-2023-01-01 | Programme name: Global Health EDCTP3 Joint Undertaking | Start submission calls: 10/05/2023 | End submission calls: 29/06/2023

The Global Health EDCTP3 Training Networks aim to train and develop skilled, innovative, and resilient African researchers, scientists, clinicians, and other public health professionals working in the area of infectious disease research. The main objective is that these professionals can face current and future clinical research challenges, efficiently carry out clinical trials, mentor young scientists, implement research results, apply knowledge into development of products and services and/or analyse data to inform policy and practice for better health for all in sub-Saharan Africa (SSA). Through the training being offered to the fellows, important research questions within the framework of the Strategic Research and Innovation Agenda of Global Health EDCTP3 will be addressed.